Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease
نویسندگان
چکیده
منابع مشابه
Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress
Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding the identification of potential therapy. Using an integrative approach at the isolated organ, cellular and molecular levels, we tested the hypothesis that oxidative stress ...
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Cardiovascular disease (CVD) presents a global health burden, despite recent advances in management. CVD can originate from early life by so-called "developmental origins of health and disease" (DOHaD). Epidemiological and experimental evidence supports that early-life insults can induce programming of later CVD. Underlying the DOHaD concept, early intervention may offset programming process to...
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Hypoxia-ischemia (HI) is characterized by a reduced supply of oxygen during pregnancy, which leads to both central nervous system and peripheral injuries in the foetus, resulting in impairment in its development. The purpose of this study was to investigate behavioural changes and systemic oxidative stress in adult animals that have been affected by HI during pregnancy. HI was induced by the oc...
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ardiovascular risk factors are identifiable in childhood and are predictive of adulthood risk for coronary artery disease.1 Autopsy studies of youths have established a strong association between cardiovascular risk factors and early stages of coronary atherosclerosis.2 Longitudinal observation studies have shown that coronary heart disease (CHD) risk factors measured in adolescence predict mar...
متن کاملOxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer.
In the developing embryo and fetus, endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS) like hydroxyl radicals may adversely alter development by oxidatively damaging cellular lipids, proteins and DNA, and/or by altering signal transduction. The postnatal consequences may include an array of birth defects (teratogenesis), postnatal functional deficits, and diseases. In ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2017
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00245.2017